Case Study: Major Depressive Disorder (Severe, Non-Psychotic)

Integrated pharmacotherapy and psychotherapy for a working-age adult with severe depressive symptoms, assessed with PHQ‑9 and monitored for functional recovery — aligned with Aleta’s clarity and clinical rigor.

Patient Profile

Patient: Mr. Sameer Joshi, 35-year-old male
Chief Complaint: Persistent sadness, fatigue, and loss of interest for 6 weeks

History & Examination

  • Medical history: No prior psychiatric diagnoses
  • Symptoms: Insomnia, poor concentration, passive suicidal ideation
  • Mental status exam: Psychomotor retardation; no hallucinations or delusions

Investigations

  • PHQ‑9: 21 (severe depression)
  • Thyroid profile: Normal
  • CBC and Vitamin B12: Normal

Diagnosis

Major Depressive Disorder (single episode, severe, without psychotic features) — based on DSM‑5 criteria and PHQ‑9 scoring.

Management Plan

Pharmacological

  • Sertraline 50 mg daily to start; titrate per response and tolerability
  • Melatonin at night to support sleep

Psychotherapy

  • Cognitive Behavioral Therapy (CBT): Weekly structured sessions
  • Supportive counseling and psychoeducation

Safety & Follow‑up

  • 2 weeks: Check side effects, mood, and adherence
  • Monthly: Reassess PHQ‑9, therapy progress, and functioning
  • Crisis plan: Provide hotline and rapid-access contact; review suicidality at each visit

Outcome Goals

  • Reduce PHQ‑9 to < 5
  • Restore functional capacity at work and home
  • Prevent relapse and maintain remission

Long‑Term Considerations

  • Continue therapy for 6–12 months after remission
  • Monitor adherence, side effects, and relapse warning signs
  • Encourage social engagement, sleep hygiene, and physical activity

References

  • American Psychological Association — Depression Guideline Case Examples.
  • University of Auckland — Writing a Psychiatric Case History (PDF Guide).